actinomycin

actinomycin
A group of peptide antibiotic agents, isolated from several species of Streptomyces (originally Actinomyces), that are active against Gram-positive bacteria, fungi, and neoplasms. Actinomycins are chromopeptides, most containing the chromophore actinocin, and are derivatives of phenoxazine that differ in their amino acid s and their sequence in the peptide chains; they form complexes with DNA and therefore inhibit RNA synthesis, primarily the ribosomal type.
- a. A the first of the actinomycins isolated in crystalline form.
- a. C SYN: cactinomycin.
- a. D SYN: dactinomycin.
- a. F1 KS4; produced by a. C-elaborating strains of Streptomyces chrysomallus; used as an antineoplastic agent.

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ac·ti·no·my·cin -'mīs-ən n any of various red or yellow-red mostly toxic polypeptide antibiotics isolated from soil bacteria (esp. Streptomyces antibioticus) specif one used to inhibit DNA or RNA synthesis

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ac·ti·no·my·cin (ak″tĭ-no-miґsin) a large, complex family of antibiotics obtained from cultures of various species of Streptomyces, which have antibacterial, antifungal, and cytotoxic properties. Actinomycin D (see dactinomycin) is an antineoplastic agent.

Medical dictionary. 2011.

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  • Actinomycin — D Systematic (IUPAC) name 2 amino N,N bis[(6S,9R,10S,13R,18aS) 6,13 diisopropyl 2,5,9 trimethyl 1,4,7,11,14 pentaoxohexadecahydro 1H pyrrolo[2,1 i] [1,4,7,10,13] oxatetraazacyclohexadecin 10 yl] 4,6 dimethyl 3 oxo 3H …   Wikipedia

  • actinomycin — n. [From actinomyces, the genus of the organism in which they were first found.] 1. any of various red antibiotics isolated from soil bacteria with a three ring heterocyclic nucleus with an attached peptide chain. Note: Actinomycin D is the most… …   The Collaborative International Dictionary of English

  • actinomycin C — actinomycin actinomycin n. [From actinomyces, the genus of the organism in which they were first found.] 1. any of various red antibiotics isolated from soil bacteria with a three ring heterocyclic nucleus with an attached peptide chain. Note:… …   The Collaborative International Dictionary of English

  • actinomycin D — actinomycin actinomycin n. [From actinomyces, the genus of the organism in which they were first found.] 1. any of various red antibiotics isolated from soil bacteria with a three ring heterocyclic nucleus with an attached peptide chain. Note:… …   The Collaborative International Dictionary of English

  • actinomycin F1 — actinomycin actinomycin n. [From actinomyces, the genus of the organism in which they were first found.] 1. any of various red antibiotics isolated from soil bacteria with a three ring heterocyclic nucleus with an attached peptide chain. Note:… …   The Collaborative International Dictionary of English

  • actinomycin D — n. [From actinomyces, the genus of the organism in which they were first found.] The most well known of the actinomycins ({C62H86N12O16}), a class of antibiotics which act by binding to DNA and inhibiting synthesis of RNA; they act agains gram… …   The Collaborative International Dictionary of English

  • actinomycin D — actinomycin D. См. актиномицин D. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • actinomycin D — n DACTINOMYCIN * * * see dactinomycin …   Medical dictionary

  • actinomycin — ☆ actinomycin [ak΄tə nōmī′sin ] n. [< ACTINOMYCETE + IN1] any of various antibiotic polypeptides derived from streptomyces soil bacteria: active against certain bacteria and fungi and some neoplasms …   English World dictionary

  • Actinomycin D — Strukturformel Allgemeines Freiname Actinomycin D Andere Namen …   Deutsch Wikipedia

  • Actinomycin — Actinomycine sind eine Klasse von Peptid Antibiotika aus Streptomyceten. Inhaltsverzeichnis 1 Struktureller Aufbau 2 Entdeckung und Nomenklatur 3 Biologische Wirkung 4 Pharmakologische Anwendung …   Deutsch Wikipedia

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