Placental hormone that reaches maximum levels in maternal serum during labor. [active + -in]

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ac·ti·vin (akґtĭ-vin) any of several polypeptide growth and differentiation factors, members of the transforming growth factor-β superfamily of proteins, that are synthesized in the pituitary gland and gonads and stimulate the secretion of follicle-stimulating hormone; they also play roles in neuroendocrine regulation, modulate production of other hormones, and affect gonadal functions such as steroid production. They are signaling proteins that act through a heteromeric complex of receptor serine/threonine kinases, signaling particular transcriptional responses. Their actions oppose those of inhibins (q.v.), with which they share subunits, the activins comprising dimers of either or both of the inhibin beta subunits.

Medical dictionary. 2011.

Look at other dictionaries:

  • Activin — Protein Name=inhibin, beta A (activin A, activin AB alpha polypeptide) caption=The Activin dimer, from 2ARV.pdb Symbol=INHBA AltSymbols= HGNCid=6066 Chromosome=7 Arm=p Band= LocusSupplementaryData=15 p13 ECnumber= OMIM=147290 EntrezGene=3624… …   Wikipedia

  • Activin — Inhibin Beta A Kette (Dimer) Struktur von PDB 2ARV Inhibin ist im menschlichen Organismus ein als Glykoprotein gebildetes Proteohormon, welches in den Sertolizellen der Hoden und in den Granulosazellen der Eierstöcke gebildet wird. Es reguliert… …   Deutsch Wikipedia

  • activin — b subunits of inhibin (which is an ab heterodimer) ; since there are two isoforms, A and B, there are three forms of activin, AA, BB and AB. Receptor has serine/threonine kinase activity in its cytoplasmic domain …   Dictionary of molecular biology

  • activin — ac·ti·vin (ăkʹtə vĭn, ăk tĭvʹĭn) n. A polypeptide growth factor that is synthesized in the pituitary gland and the gonads and stimulates the secretion of follicle stimulating hormone.   [activate + inhibin(from its activating follicle stimulating …   Universalium

  • activin — noun A peptide that participates in the regulation of the menstrual cycle, cell proliferation, apoptosis, metabolism, and many other diverse functions. See Also: inhibin …   Wiktionary

  • Activin type 2 receptors — The Activin type 2 receptors modulate signals for ligands belonging to the Transforming growth factor beta superfamily of ligands. These include: Activin (or Inhibin), Bone morphogenetic proteins and Nodal. They are involved in a host of… …   Wikipedia

  • Activin receptor — An Activin receptor is a receptor which binds activin.Types include: * Activin type 1 receptors * Activin type 2 receptorsExternal links* …   Wikipedia

  • Activin type 1 receptors — The Activin type I receptors transduce signals for a variety of members of the Transforming growth factor beta superfamily of ligands. This family of cytokines and hormones include activin, Anti müllerian hormone (AMH), bone morphogenetic… …   Wikipedia

  • activin-response factor — Induced in early Xenopus blastomeres by activin, Vg 1 and TGF b, binds to activin response element in the mix 2 homeobox gene. The ARF complex contains XMAD2, a Xenopus homologue of the Drosophila Mad gene product, and FAST 1, a winged helix… …   Dictionary of molecular biology

  • ACVR1B — Activin A receptor, type IB, also known as ACVR1B, is a human gene.cite web | title = Entrez Gene: ACVR1B activin A receptor, type IB| url = Cmd=ShowDetailView TermToSearch=91| accessdate = ]… …   Wikipedia

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