tumour necrosis factor


tumour necrosis factor
either of two proteins, TNF-a or TNF-b, that function as cytokines. Among their many actions is destruction of tumour cells. The gene encoding TNF has been used in gene therapy trials for cancer.

Medical dictionary. 2011.

Look at other dictionaries:

  • tumour necrosis factor — TNF a or cachectin, originally described as a tumour inhibiting factor in the blood of animals exposed to bacterial lipopolysaccharide or Bacille Calmette Guerin (BCG). Preferentially kills tumour cells in vivo and in vitro , causes necrosis of… …   Dictionary of molecular biology

  • tumour necrosis factor — noun a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis) • Syn: ↑tumor necrosis factor, ↑TNF • Hypernyms: ↑cytokine …   Useful english dictionary

  • tumour necrosis factor — TNF either of two proteins, TNF α or TNF β, that function as cytokines. Produced by macrophages, monocytes, T lymphocytes, and various other cells, they mediate many responses, including inflammation, and have a marked action against tumour cells …   The new mediacal dictionary

  • tumour necrosis factor — ▪ pathology also called  cachectin        a naturally occurring protein that is produced in the human body by the phagocytic cells known as macrophages. (The latter can engulf and destroy bacteria, viruses, and other foreign substances.) TNF is… …   Universalium

  • Фактор Опухолевый Некротический (Tumour Necrosis Factor (Tnf)) — специфический белок, вызывающий разрушение опухолевых клеток. Ген, кодирующий некротический опухолевый фактор, используется в экспериментальных генетических исследованиях, связанных с изучением и лечением злокачественных опухолей. Источник:… …   Медицинские термины

  • See tumour necrosis factor. — См. tobacco mosaic virus …   Dictionary of molecular biology

  • tumor necrosis factor — noun a proinflammatory cytokine that is produced by white blood cells (monocytes and macrophages); has an antineoplastic effect but causes inflammation (as in rheumatoid arthritis) • Syn: ↑tumour necrosis factor, ↑TNF • Hypernyms: ↑cytokine * * * …   Useful english dictionary

  • Tumor necrosis factor-alpha — Tumor necrosis factor (TNF, cachexin or cachectin and formally known as tumor necrosis factor alpha ) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF causes… …   Wikipedia

  • Tumor necrosis factor receptor — TNFR/NGFR cysteine rich region Structure of the soluble human 55 kd TNF receptor human TNF beta complex[1]. Identifiers Symbol …   Wikipedia

  • tumour-infiltrating lymphocyte — a lymphoid cell that can infiltrate solid tumours. Such cells can be cultured in vitro, in the presence of interleukin 2, and have been used as vehicles for tumour necrosis factor in gene therapy trials for cancer …   Medical dictionary


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