- A person possessing two different forms of a particular gene, one inherited from each parent. A heterozygote is also called a carrier. For example, a woman who is a heterozygote for cystic fibrosis (CF) carries the CF gene on one of her chromosomes number 7 and the normal paired (non-CF) gene at the same position on her other chromosome 7. She is a carrier for CF but has no signs or symptoms of the disease. A manifesting heterozygote is a person who manifests signs or symptoms of what is usually a recessive condition and ordinarily only is evident in someone who has two copies of the gene. A compound heterozygote has two different mutant forms of a particular gene.
* * *A heterozygous individual. [hetero- + G. zygotos, yoked]- compound h. in medical genetics, the presence of two different mutant alleles at the same loci. SYN: genetic compound.- manifesting h. an organism heterozygous for what is ordinarily a recessive condition which, as a result of special mechanisms (such as lyonization, allelic exclusion, or a deletion in the homologous chromosome), has phenotypic manifestations. SYN: manifesting carrier.
* * *het·ero·zy·gote -'zī-.gōt n a heterozygous individualhet·ero·zy·got·ic -(.)zī-'gät-ik adj
* * *het·ero·zy·gote (het″ər-o-ziґgōt) [hetero- + zygote] an individual exhibiting heterozygosity.
Medical dictionary. 2011.