A cell hybrid resulting from the fusion of a cancer cell and a normal lymphocyte (a type of white blood cell). The hybridoma is immortal in the laboratory and makes the same products as its parent cells forever.
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A tumor of hybrid cells used in the in vitro production of specific monoclonal antibodies; produced by fusion of an established tissue culture line of lymphocyte tumor cells ( e.g., mouse plasmacytoma cells) and specific antibody-producing cells ( e.g., splenocytes from specifically immunized mice); fusions are accomplished by use of polyethylene glycol or other methods. [G. hybris, violation, wantonness, + -oma, tumor]

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hy·brid·oma .hī-brə-'dō-mə n a hybrid cell produced by the fusion of an antibody-producing lymphocyte with a tumor cell and used to culture continuously a specific monoclonal antibody

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hy·brid·o·ma (hi″brid-oґmə) [hybrid + -oma] a somatic cell hybrid formed by fusion of normal lymphocytes and tumor cells; the resulting hybridoma cells will produce the same secretion as the normal parent cells and proliferate indefinitely in culture like the parent tumor cells.

Medical dictionary. 2011.

Look at other dictionaries:

  • Hybridoma — are cells that have been engineered to produce a desired antibody in large amounts. To produce monoclonal antibodies, B cells are removed from the spleen of an animal that has been challenged with the relevant antigen. These B cells are then… …   Wikipedia

  • hybridoma — hybridoma. См. гибридома. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • hybridoma — [hī΄bri dō′mə] n. [ HYBRID + (MYEL)OMA] a tissue culture consisting of cancer cells fused to lymphocytes to mass produce a specific antibody …   English World dictionary

  • Hybridoma — Abb.1: (1) Immunisation einer Maus; (2) Isolation von B Zellen aus der Milz; (3) Kultivierung von Myelomazellen; (4) Fusionierung von B und Myelomzelle; (5) Selektion und Screening geeigneter Zelllinien; (6) Weiterverarbeitung bzw. Aufbewahrung… …   Deutsch Wikipedia

  • hybridoma — noun Date: 1978 a hybrid cell produced by the fusion of an antibody producing lymphocyte with a tumor cell and used to culture continuously a specific monoclonal antibody …   New Collegiate Dictionary

  • hybridoma — (hi brī do mah) A fast growing cell line produced by fusing a cancer cell (myeloma) to another cell, such as an antibody producing cell …   Dictionary of microbiology

  • hybridoma — A cell hybrid in which a tumour cell forms one of the original source cells. In practice, confined to hybrids between T or B lymphocytes and appropriate myeloma cell lines …   Dictionary of molecular biology

  • hybridoma — /huy bri doh meuh/, n., pl. hybridomas. Biotech. a hybrid cell made in the laboratory by fusing a normal cell with a cancer cell, usu. a myeloma or lymphoma, in order to combine desired features of each, as the ability of the cancer cell to… …   Universalium

  • hybridoma — noun A hybrid cell engineered from a lymphocyte and a tumour cell; used to generate monoclonal antibodies …   Wiktionary

  • hybridoma — hy·bri·do·ma …   English syllables