thrombasthenia
An abnormality of platelets characteristic of Glanzmann t.. SEE ALSO: Bernard-Soulier syndrome. SYN: thromboasthenia. [thromb- + G. astheneia, weakness]
- Glanzmann t. [MIM*273800] a hemorrhagic diathesis characterized by normal or prolonged bleeding time, normal coagulation time, defective clot retraction, normal platelet count but morphologic or functional abnormality of platelets; several different kinds of platelet abnormalities have been described; caused by defect in platelet membrane glycoprotein IIb-IIIa complex; autosomal recessive inheritance, caused by mutation in the platelet-membrane glycoprotein IIb-IIIa complex gene (ITGA2B) on chromosome 17. SYN: constitutional thrombopathy, Glanzmann disease, hereditary hemorrhagic t..

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throm·bas·the·nia .thrām-bəs-'thē-nē-ə n an inherited abnormality of the blood platelets characterized esp. by defective clot retraction and often by prolonged bleeding time

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n.
a hereditary blood disease in which the function of the platelet is defective although they are present in normal numbers. The manifestations are identical to those of thrombocytopenic purpura.

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throm·bas·the·nia (throm″bəs-theґne-ə) [thrombocyte + astheneia] 1. decreased platelet function; called also thromboasthenia. 2. Glanzmann t.

Medical dictionary. 2011.

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