- An abnormality of platelets characteristic of Glanzmann t.. SEE ALSO: Bernard-Soulier syndrome. SYN: thromboasthenia. [thromb- + G. astheneia, weakness]- Glanzmann t. [MIM*273800] a hemorrhagic diathesis characterized by normal or prolonged bleeding time, normal coagulation time, defective clot retraction, normal platelet count but morphologic or functional abnormality of platelets; several different kinds of platelet abnormalities have been described; caused by defect in platelet membrane glycoprotein IIb-IIIa complex; autosomal recessive inheritance, caused by mutation in the platelet-membrane glycoprotein IIb-IIIa complex gene (ITGA2B) on chromosome 17. SYN: constitutional thrombopathy, Glanzmann disease, hereditary hemorrhagic t..
* * *throm·bas·the·nia .thrām-bəs-'thē-nē-ə n an inherited abnormality of the blood platelets characterized esp. by defective clot retraction and often by prolonged bleeding time
* * *n.a hereditary blood disease in which the function of the platelet is defective although they are present in normal numbers. The manifestations are identical to those of thrombocytopenic purpura.
* * *throm·bas·the·nia (throm″bəs-theґne-ə) [thrombocyte + astheneia] 1. decreased platelet function; called also thromboasthenia. 2. Glanzmann t.
Medical dictionary. 2011.
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thrombasthenia — Condition in which there is defective platelet aggregation, though adherence is normal. See Glanzmann s thrombasthenia … Dictionary of molecular biology
thrombasthenia — throm·bas·the·nia … English syllables
thrombasthenia — n. a hereditary blood disease in which the function of the platelets is defective although they are present in normal numbers. The manifestations are identical to those of thrombocytopenic purpura … The new mediacal dictionary
thrombasthenia — noun a rare autosomal recessive disease in which the platelets do not produce clots in the normal way and hemorrhage results • Hypernyms: ↑autosomal recessive disease, ↑autosomal recessive defect * * * ˌthrämbəsˈthēnēə noun Etymology: New Latin,… … Useful english dictionary
Glanzmann's thrombasthenia — Infobox Disease Name = PAGENAME Caption = DiseasesDB = 5224 ICD10 = ICD10|D|69|1|d|65 ICD9 = ICD9|287.1 ICDO = OMIM = 187800 OMIM mult = OMIM2|273800 | MedlinePlus = eMedicineSubj = med eMedicineTopic = 872 MeshID = D013915 Glanzmann s… … Wikipedia
Glanzmann thrombasthenia (disease) — Glanz·mann thrombasthenia (disease) (glahntsґmən) [Eduard Glanzmann, Swiss pediatrician, 1887â€“1959] see thrombasthenia … Medical dictionary
Glanzmann thrombasthenia — a hereditary platelet abnormality characterized by defective clot retraction, prolonged bleeding time, and related symptoms such as epistaxis and inappropriate bleeding. Clinically there is abnormal glass adhesion and impaired aggregation to ADP … Medical dictionary
Glanzmann's thrombasthenia — Platelet dysfunction in which aggregation is deficient. A specific glycoprotein complex (IIb/IIIa) is absent from the plasma membrane: this seems to be the fibronectin/fibrinogen receptor and is a b3 integrin … Dictionary of molecular biology
constitutional thrombocytopathy — thrombasthenia … Medical dictionary
Coagulation — This article is about blood clotting. For other meanings see Coagulation (disambiguation). Coagulation is a complex process by which blood forms clots. It is an important part of hemostasis, the cessation of blood loss from a damaged vessel,… … Wikipedia