- Condensation product of coenzyme A and acetic acid, symbolized as CoAS∼COCH3; intermediate in transfer of two-carbon fragment, notably in its entrance into the tricarboxylic acid cycle and in fatty acid synthesis. SYN: acetyl-coenzyme A, active acetate.- acetyl-CoA acetyltransferase an acetyltransferase forming acetoacetyl-CoA from two molecules of acetyl-CoA, releasing one CoA. A key step in ketogenesis and sterol synthesis. SYN: acetoacetyl-CoA thiolase, acetyl-CoA thiolase, thiolase.- acetyl-CoA acylase SYN: acetyl-CoA hydrolase.- acetyl-CoA acyltransferase an enzyme catalyzing the thioclastic cleavage by coenzyme A of β-ketoacyl-CoA, forming an acyl-CoA with a carbon chain shorter by two atoms, the missing two atoms appearing as acetyl-CoA. A step in fatty acid degradation. SEE ALSO: acetyl-CoA acetyltransferase. SYN: 3-ketoacyl-CoA thiolase, β-ketothiolase.- acetyl-CoA carboxylase a ligase that catalyzes the reaction of acetyl-CoA, CO2, H2O, and ATP, with a divalent cation as catalyst and covalently bound biotin, to form malonyl-CoA, ADP, and Pi (or the reverse decarboxylase); N-carboxybiotin is an intermediate. A crucial enzyme in fatty acid synthesis.- acetyl-CoA deacylase SYN: acetyl-CoA hydrolase.- acetyl-CoA:α-glucosaminide acetyltransferase an enzyme involved in the synthesis of certain carbohydrate moieties on proteins. A deficiency of this enzyme leads to mucopolysaccharidosis type III C.- acetyl-CoA hydrolase a hydrolase that cleaves acetate and coenzyme A from acetyl-CoA. SYN: acetyl-CoA acylase, acetyl-CoA deacylase.- acetyl-CoA ligase a ligase that catalyzes the reaction of acetate and CoA and ATP to form AMP, pyrophosphate, and acetyl-CoA. A key step in the activation of acetate. SYN: acetate thiokinase, acetate-CoA ligase, acetyl-activating enzyme, acetyl-CoA synthetase.* * *acetyl coenzyme A
Medical dictionary. 2011.